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Breast cancer patients welcome genomic test that predicts risk of recurrence E-mail
Wednesday, October 17, 2007
New research from the University of North Carolina at Chapel Hill and the National Institutes of Health finds most breast cancer patients would be receptive to a new genomic test that can determine the chance of breast cancer recurrence and help plan treatment.

New research from the University of North Carolina at Chapel Hill and the National Institutes of Health finds most breast cancer patients would be receptive to a new genomic test that can determine the chance of breast cancer recurrence and help plan treatment.

Currently, breast cancer physicians make treatment decisions and predict the risk of recurrence based largely on the location and size of the tumor and if the cancer has spread to lymph nodes and distant sites of the body. But not all patients who are similar in terms of these clinical indicators get the same benefits from treatment.

In an attempt to remedy that situation, scientists studying the genetics of breast cancer at UNC and elsewhere have identified a number of patterns in the genes of individual tumors that make them biologically different from others and which could provide valuable clinical information, such as how likely the tumors are to be invasive, how well they might respond to different treatments and how likely they are to recur or spread.

While the test is still under study and a not yet a part of clinical care, it appears that such differences in gene expression patterns may be used to individually tailor treatment.

The new study, from UNC’s Lineberger Comprehensive Cancer Center, School of Public Health and department of psychology in the College of Arts & Sciences is the first to demonstrate breast cancer patients’ interest in genomic risk testing and how these results might influence decisions about adjuvant care.

The UNC study, led by Noel Brewer, Ph.D., assistant professor of health behavior and health education in the School of Public Health, asked 139 women who were treated for early-stage breast cancer questions that presented hypothetical scenarios reflecting different test outcomes and potential treatment decisions.

“We assessed women’s attitudes towards risk for recurrence testing, how results would affect their choices about adjuvant treatment, and potential concerns about and perceived benefits of testing,” said Dr. Suzanne O’Neill of the National Human Genome Research Institute, part of the National Institutes of Health, who was involved in the study.

The study, published Oct. 10, 2007, in the Journal of Clinical Oncology, found most patients would have been interested in a genomic test that showed their risk for recurrence at the time they were treated, had it been available. The majority said they would “definitely” want to be tested (76 percent), receive their results (87 percent), and discuss these results with their physicians.

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