|UNC study shows potential to revive abandoned cancer drug by nanoparticle drug delivery|
|Wednesday, May 02, 2012|
They developed nanoparticle carriers to successfully deliver therapeutic doses of a cancer drug that had previously failed clinical development due to pharmacologic challenges. They report their proof of principle findings in the April 30, 2012 early online edition of Proceedings of the National Academy of Sciences.
Wortmannin is a drug that was highly promising as a cancer drug, butits successful preclinical studies did not translate into clinical efficacy because of challenges such as high toxicity, low stability and low solubility(unable to be dissolved in blood).
CAROLINA IN THE NEWSWith exposure to babies, rodent dads’ brains, like moms’, become wired for nurture
The Washington Post
...Sue Carter, a behavioral neurobiologist at the University of North Carolina at Chapel Hill, has spent her career studying prairie voles: “Sometimes they midwife the birth. They grab the baby and start licking it before it’s even out of the membrane it’s born in.” Carter’s studies, like Lambert’s, have found that virgin male prairie voles, when exposed to pups, experience a surge of the hormones oxytocin and vasopressin, the so-called “love” hormones that encourage social bonding, much as mothers do.