|Discovery suggests new combination therapy strategy for basal-like breast cancers|
|Monday, May 21, 2012|
Multiple research projects – including a 2006 study conducted at the University of North Carolina at Chapel Hill – have used DNA microarray analysis to identify several breast cancer subtypes, including luminal A, luminal B, basal-like and HER2-enriched. Simple tests are being developed to help doctors identify these subtypes and to treat their patients in a more biologically-based way. In turn, these tests have made several studies possible that indicate that basal-like, or triple negative breast cancer, is more prevalent in African Americans than their Caucasian counterparts.
A new study led by UNC Lineberger scientist Charles Perou, PhD, and Sean Egan, PhD, from The Hospital for Sick Children in Toronto, Ontario, demonstrates that deletion of a sugar transferase called LFNG (nicknamed “lunatic fringe”), promotes cell proliferation and tumor formation of basal-like breast cancers.
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CAROLINA IN THE NEWSUNC's Loren Shealy wins SI's female College Athlete of the Year award
The phrase has been hollowed out by years of often cynical misapplication, but every once in a while a special collegian gives the term student-athlete unassailable substance. Meet SI's female College Athlete of the Year, North Carolina sophomore Loren Shealy, an ace field hockey forward, top business administration student, Robertson Scholar and, for one lunch hour in late April, just one of the scores of UNC students who have stopped for a meal or conversation at the Pit, the oak-shaded sunken brick courtyard that serves as the village square of the Chapel Hill campus.